Mild gastrointestinal effects, particularly diarrhoea, nausea and vomiting, abdominal pain, flatulence, dyspepsia, and anorexia. Serum-amylase concentrations may be raised and pancreatitis has been reported. Hypophosphataemia. Skin rashes. Peripheral neuropathy, headache, dizziness, insomnia, depression, asthenia, sweating, and myalgia. Raised liver enzymes, hypertriglyceridaemia, hyperglycaemia, and neutropenia. Renal impairment, (including Fanconi syndrome). Lactic acidosis, severe hepatomegaly and steatosis.