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Pantostad 40 CAP

Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production.
  • Box of 28 capsules
  • 24 months
  • Pantoprazole
  • 40 mg
  • Hard gelatin capsule
PRESCRIBING INFORMATION

Indications, Usage, Dosage and Administration

Indications:

  • Treatment of gastro-oesophageal reflux disease (GORD).
  • Treatment of peptic ulcer disease.
  • Prophylasis for NSAID- associated ulceration.
  • Treatment of pathological hypersecretory states (Zollinger-Ellison syndrome).

Dosage:

  • Gastro-oesophageal reflux disease: 20 – 40 mg once daily for 4 to 8 weeks; thereafter, continued with 20 to 40 mg daily; for recurring symptoms, an on-demand of 20 mg daily may be given.
  • Peptic ulcer disease: 40 mg once daily for 2 – 4 weeks (duodenal ulcer) and 4 to 8 weeks (benign gastric ulcer). For the eradication of H. pylori, 1-week effective regimens: pantoprazole 40 mg twice daily + clarithromycin 500 mg twice daily + amoxicillin 1 g twice daily or metronidazole 400 mg twice daily.
  • Prophylaxis for NSAID- associated ulceration: 20 mg daily.
  • Zollinger-Ellison syndrome: commence with 80 mg once daily, adjusted as required; doses may be up to 240 mg daily. Daily doses greater than 80 mg should be given in 2 divided doses.
  • Hepatic impairment: Reduce daily doses in severe hepatic impairment, or doses given only on alternate days. A maximum dose of 20 mg daily, or 40 mg on alternate days.
  • Renal impairment: A maximum dose is 40 mg daily.

Usage:

Pantostad 40 CAP is administered orally. Once daily doses should be taken in the morning.

Contraindications

Known hypersensitive to any of the active substance or excipients.

Adverse reactions

Diarrhea, hyperglycemia; headache, abdominal pain, abnormal liver function test results.

Precautions

  • Symptomatic response to therapy with pantoprazole does not preclude the occult presence of gastric neoplasm.
  • Mild, transient elevations of serum ALT (SGPT) have been reported with oral pantoprazole therapy.
  • Pantoprazole may lead to malabsorption of cyanocobalamin.
  • Safety and efficacy in children younger than 18 years of age have not been established.
  • Pregnancy: There are no adequate studies. Lactation: a decision should be made whether to discontinue nursing or the drug.
  • Patients should be aware of how they react to drug before driving or operating machinery.
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